Dr. Doreen DeStefano, DNP, APRN, NHD, is an integrative oncology practitioner, author, educator, speaker, and founder of Root Causes Holistic Health & Medicine in Fort Myers, Florida. With more than two decades of clinical experience, she is known for her strategic, whole-person approach to complex and chronic illness—particularly cancer.
Often described as a “medical detective,” Dr. DeStefano blends conventional oncology with cutting-edge metabolic, nutritional, immune, and precision medicine strategies. She believes that successful cancer care requires treating both the tumor and the person living with it. By identifying and addressing the biological factors that influence cancer—including chronic inflammation, mitochondrial dysfunction, immune suppression, metabolic instability, hormonal imbalance, and environmental toxic burden—she develops individualized treatment strategies designed to support the body's capacity to heal while complementing standard cancer therapies.
Dr. DeStefano is a Certified Metabolic Approach to Cancer practitioner and specializes in advanced IV nutrient therapy, photodynamic therapy (PDT), hyperbaric oxygen therapy (HBOT), local-regional hyperthermia, immune modulation, and precision testing, including circulating tumor DNA and comprehensive genomic profiling. She remains deeply committed to ongoing education, continually studying emerging research from around the world and translating the latest scientific discoveries into practical, evidence-informed clinical strategies.
Her book, Biohacking Cancer, reflects her clinical philosophy: empower patients with clarity, strategy, and actionable science so they can become active participants in their own care. She believes cancer care must evolve beyond fear-based models into intelligent, proactive, systems-based healing that addresses both the tumor and the internal environment in which it develops.
Through her books, lectures, and clinical practice, Dr. DeStefano helps patients move from overwhelm to ownership—transforming diagnosis into a roadmap for rebuilding resilience, restoring physiology, and creating the conditions for long-term health. She continues to challenge conventional thinking while helping patients and healthcare professionals understand that healing is not about chasing symptoms—it's about changing the biology that drives disease.
Learn more About Dr. D here on America's Best Doctors
https://insidesuccess.tv/programs/americasbestdoctorstv_doreen-destefano
